BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ASID Gwybodaeth sylfaenol
| Enw Cynnyrch: | BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ASID |
| Cyfystyron: | Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,(bR)-;(R)-Sitagliptin N-Boc-Acid IMpurity;Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid (3R)-N-(tert-Butoxycarbonyl)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid;Boc-(R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic acid, >=99%;(3R)-N-Boc-3-amino-4-(2,4,{8}}trifflworophenyl)asid bwtanoic;(3R)-N-(tert-Butoxycarbonyl )-3-aMino-4-(2,4,5-trifluorophenyl)-asid bwtanoic- Boc-(R)-3-AMino-4-(2,4,{ {25}}trifluorophenyl) asid bwtanoic (BOC asid);[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-(R)-benzenebuta; BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ASID |
| CAS: | 486460-00-8 |
| MW: | 333.31 |
| MF: | C15H18F3NO4 |
| EINECS: | 691-120-8 |
BOC-(R)-3-AMINO-4-}% 7d(2% 2c4,{{5}TRIFLUORO-PHENYL)-BUTYRIC ASID Cemegol Eiddo
| Ymdoddbwynt | 136-138 gradd |
| berwbwynt | 443.1±45.0 gradd (Rhagweld) |
| dwysedd | 1.292±0.06 g/cm3(Rhagweld) |
| tymheredd storio. | 2-8 gradd |
| hydoddedd | Clorofform (Ychydig), DMSO (Ychydig), Asetad Ethyl (Ychydig), Methanol (Ychydig) |
| ffurf | Solet |
| pka | 4.30±0.10(Rhagweld) |
| lliw | Gwyn i Off-Gwyn |
BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ASID Defnydd A Synthesis
| Ffurf Corfforol | Gwyn i Solid Melyn |
| Disgrifiad | Mae asid bwtyrig Boc-(R) -3-amino-4 -(2,4, 5-trifluorophenyl) yn ganolradd bwysig ar gyfer paratoi sitagliptin. Sitagliptinphosphate yw'r atalydd dipeptidase -IV(dpp-4) cyntaf a gymeradwywyd gan FDA yn 2006. Fe'i defnyddir ar gyfer trin diabetes mellitus math II. Mae ganddo effaith hypoglycemig amlwg pan gaiff ei ddefnyddio ar ei ben ei hun neu mewn cyfuniad â metformin a pioglitazone, ac mae'n ddiogel ei gymryd, wedi'i oddef yn dda, heb fawr o adweithiau niweidiol. |
| Defnyddiau | (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid wedi cael ei ddefnyddio fel adweithydd ar gyfer paratoi deupeptidyl peptidase{{6 }} (DPP4) atalyddion ar gyfer trin diabetes math 2, fel sitagliptin. |
Tagiau poblogaidd: boc-(r)-3-amino-4-(2,4,5-trifluoro-phenyl)-butyric acid cas no.486460-00-8, Tsieina, gwneuthurwyr, cyflenwyr, ffatri, arfer, cyfanwerthu
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